pears bike insulin

Diabetes Dateline
Winter 2011

Critical Link Found between Insulin and Bone

Recent research findings published in the July 23, 2010, issue of Cell shed new light on the interactions between insulin, bone, and blood glucose, also called blood sugar. The findings could lead to a new approach to treating type 2 diabetes.

People with type 2 diabetes do not secrete enough insulin to control blood glucose, and their cells and tissues have a decreased capacity to respond to the hormone. A protein called osteocalcin, which stimulates bone-forming cells called osteoblasts and is secreted by them, has the important properties of stimulating insulin production and making the body’s cells more sensitive to insulin. Osteocalcin is inactive when released by the osteoblasts but is activated by osteoclasts, a different cell type that breaks down old bone.

Research conducted in mice from two laboratories supported by the National Institutes of Health has shown that insulin also stimulates production of the active form of osteocalcin, which in turn has a beneficial impact on energy balance within the body. Thus, the research shows another important way that insulin regulates metabolism—through its effects on bone—and suggests that bone cells may be a useful therapeutic target for type 2 diabetes.

Visit www.diabetes.niddk.nih.gov for more information about diabetes.

[Top] [Next article]


NIH Publication No. 11–4562
January 2011

Page last updated: December 5, 2011


The National Diabetes Information Clearinghouse is a service of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.

National Diabetes Information Clearinghouse
1 Information Way
Bethesda, MD 20892–3560
Phone: 1–800–860–8747
TTY: 1–866–569–1162
Fax: 703–738–4929
Email: ndic@info.niddk.nih.gov
Internet: www.diabetes.niddk.nih.gov

Department of Health and Human ServicesThe National Institutes of HealthThe National Institute of Diabetes and Digestive and Kidney DiseasesUSA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services. This website is certified by Health On the Net Foundation. Click to verify.

NIH...Turning Discovery Into Health ®

Privacy Statement | Disclaimers | Accessibility | PDF versions require the free Acrobat Reader click to view disclaimer page software for viewing.